SapC-DOPS nanovesicles: a novel targeted agent for the imaging and treatment of glioblastoma
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منابع مشابه
SapC-DOPS nanovesicles: a novel targeted agent for the imaging and treatment of glioblastoma
Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor. Classified by the World Health Organization (WHO) as grade IV astrocytoma, GBMs are extremely aggressive, almost always recur, and despite our best efforts, remain incurable. This review describes the traditional treatment approaches that led to moderate successes in GBM patients, discusses standard imaging modaliti...
متن کاملTargeting and Cytotoxicity of SapC-DOPS Nanovesicles in Pancreatic Cancer
Only a small number of promising drugs target pancreatic cancer, which is the fourth leading cause of cancer deaths with a 5-year survival of less than 5%. Our goal is to develop a new biotherapeutic agent in which a lysosomal protein (saposin C, SapC) and a phospholipid (dioleoylphosphatidylserine, DOPS) are assembled into nanovesicles (SapC-DOPS) for treating pancreatic cancer. A distinguishi...
متن کاملCytotoxicity and Selectivity in Skin Cancer by SapC-DOPS Nanovesicles.
Squamous cell carcinoma (SCC) and melanoma are malignant human cancers of the skin with an annual mortality that exceed 10,000 cases every year in the USA alone. In this study, the lysosomal protein saposin C (SapC) and the phospholipid dioloylphosphatidylserine (DOPS) were assembled into cancer-selective nanovesicles (SapC-DOPS) and successfully tested using several in vitro and in vivo skin c...
متن کاملIn Vivo Optical Imaging of Brain Tumors and Arthritis Using Fluorescent SapC-DOPS Nanovesicles
We describe a multi-angle rotational optical imaging (MAROI) system for in vivo monitoring of physiopathological processes labeled with a fluorescent marker. Mouse models (brain tumor and arthritis) were used to evaluate the usefulness of this method. Saposin C (SapC)-dioleoylphosphatidylserine (DOPS) nanovesicles tagged with CellVue Maroon (CVM) fluorophore were administered intravenously. Ani...
متن کاملCorrection: Targeting and Cytotoxicity of SapC-DOPS Nanovesicles in Pancreatic Cancer
Fig. 1 is incorrect. The Western blot in Fig. 1E displays the incorrect cell line. The authors have provided a corrected version here. open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ژورنال
عنوان ژورنال: Oncoscience
سال: 2015
ISSN: 2331-4737
DOI: 10.18632/oncoscience.122